Publications

Maltose-bis(hydroxymethyl)phenol (MBPs) and Maltose-tris(hydroxymethyl)phenol (MTPs) Amphiphiles for Membrane Protein Stability.

Ehsan M, Wang H, Cecchetti C, Mortensen JS, Du Y, Hariharan P, Nygaard A, Lee HJ, Ghani L, Guan L, Loland CJ, Byrne B, Kobilka BK, Chae PS. ACS Chem Biol. 2021 Sep 17;16(9):1779-1790. doi: 10.1021/acschembio.1c00578.

Conformationally flexible core-bearing detergents with a hydrophobic or hydrophilic pendant: Effect of pendant polarity on detergent conformation and membrane protein stability.

Sadaf A, Kim S, Bae HE, Wang H, Nygaard A, Uegaki Y, Du Y, Munk CF, Katsube S, Sung Lee H, Bae J, Choi CW, Choi HJ, Byrne B, Gellman SH, Guan L, Loland CJ, Kobilka BK, Im W, Chae PS. Acta Biomater. 2021 Jul 1;128:393-407. doi: 10.1016/j.actbio.2021.04.043.

Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers

Cohen AA, Yang Z, Gnanapragasam PNP, Ou S, Dam KA, Wang H, Bjorkman PJ. PLoS One. 2021;16(3):e0247963. doi: 10.1371/journal.pone.0247963.

Diastereomeric Cyclopentane-Based Maltosides (CPMs) as Tools for Membrane Protein Study

Das M, Mahler F, Hariharan P, Wang H, Du Y, Mortensen JS, Patallo EP, Ghani L, Glück D, Lee HJ, Byrne B, Loland CJ, Guan L, Kobilka BK, Keller S, Chae PS. J Am Chem Soc. 2020 Dec 23;142(51):21382-21392. doi: 10.1021/jacs.0c09629.

New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability

Ehsan M, Katsube S, Cecchetti C, Du Y, Mortensen JS, Wang H, Nygaard A, Ghani L, Loland CJ, Kobilka BK, Byrne B, Guan L, Chae PS. ACS Chem Biol. 2020 Jun 19;15(6):1697-1707. doi: 10.1021/acschembio.0c00316.

Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody

Yang Z, Wang H, Liu AZ, Gristick HB, Bjorkman PJ. Nat Struct Mol Biol. 2019 Dec;26(12):1167-1175. doi: 10.1038/s41594-019-0344-5.

A functional enrichment test for molecular convergent evolution finds a clear protein-coding signal in echolocating bats and whales

Marcovitz A, Turakhia Y, Chen HI, Gloudemans M, Braun BA, Wang H, Bejerano G. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21094-21103. doi: 10.1073/pnas.1818532116.

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.

Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West AP Jr, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC. Nature. 2019 Jun;570(7762):468-473. doi: 10.1038/s41586-019-1250-z.

Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion

Wang H, Barnes CO, Yang Z, Nussenzweig MC, Bjorkman PJ. Cell Host Microbe. 2018 Oct 10;24(4):579-592.e4. doi: 10.1016/j.chom.2018.09.003.

X-ray and EM structures of a natively glycosylated HIV-1 envelope trimer

Gristick HB, Wang H, Bjorkman PJ. Acta Crystallogr D Struct Biol. 2017 Oct 1;73(Pt 10):822-828. doi: 10.1107/S2059798317013353.

Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies

Wang H, Gristick HB, Scharf L, West AP, Galimidi RP, Seaman MS, Freund NT, Nussenzweig MC, Bjorkman PJ. Elife. 2017 May 26;6. doi: 10.7554/eLife.27389.

Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller

Freund NT, Wang H, Scharf L, Nogueira L, Horwitz JA, Bar-On Y, Golijanin J, Sievers SA, Sok D, Cai H, Cesar Lorenzi JC, Halper-Stromberg A, Toth I, Piechocka-Trocha A, Gristick HB, van Gils MJ, Sanders RW, Wang LX, Seaman MS, Burton DR, Gazumyan A, Walker BD, West AP Jr, Bjorkman PJ, Nussenzweig MC. Sci Transl Med. 2017 Jan 18;9(373). doi: 10.1126/scitranslmed.aal2144.

Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop

Wang H, Cohen AA, Galimidi RP, Gristick HB, Jensen GJ, Bjorkman PJ. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7151-E7158. doi: 10.1073/pnas.1615939113.

Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env

Scharf L, Wang H, Gao H, Chen S, McDowall AW, Bjorkman PJ. Cell. 2015 Sep 10;162(6):1379-90. doi: 10.1016/j.cell.2015.08.035.